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Proteasomal Degradation of Eukaryotic Elongation Factor-2 Kinase (EF2K) Is Regulated by cAMP-PKA Signaling and the SCF(βTRCP) Ubiquitin E3 Ligase

Protein translation and degradation are critical for proper protein homeostasis, yet it remains unclear how these processes are dynamically regulated, or how they may directly balance or synergize with each other. An important translational control mechanism is the Ca(2+)/calmodulin-dependent phosph...

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Autors principals: Wiseman, Shari L., Shimizu, Yoshio, Palfrey, Clive, Nairn, Angus C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682579/
https://ncbi.nlm.nih.gov/pubmed/23640883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.477182
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