Each Member of the Poly-r(C)-binding Protein 1 (PCBP) Family Exhibits Iron Chaperone Activity toward Ferritin

The mechanisms through which iron-dependent enzymes receive their metal cofactors are largely unknown. Poly r(C)-binding protein 1 (PCBP1) is an iron chaperone for ferritin; both PCBP1 and its paralog PCBP2 are required for iron delivery to the prolyl hydroxylase that regulates HIF1. Here we show th...

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Detalhes bibliográficos
Main Authors: Leidgens, Sebastien, Bullough, Kimberly Z., Shi, Haifeng, Li, Fengmin, Shakoury-Elizeh, Minoo, Yabe, Toshiki, Subramanian, Poorna, Hsu, Emory, Natarajan, Navin, Nandal, Anjali, Stemmler, Timothy L., Philpott, Caroline C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682578/
https://ncbi.nlm.nih.gov/pubmed/23640898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.460253
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