Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase

Although cells express hundreds of metalloenzymes, the mechanisms by which apoenzymes receive their metal cofactors are largely unknown. Poly(rC)-binding proteins PCBP1 and PCBP2 are multifunctional adaptor proteins that bind iron and deliver it to ferritin for storage or to prolyl and asparagyl hyd...

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Autori principali: Frey, Avery G., Nandal, Anjali, Park, Jong Hwan, Smith, Pamela M., Yabe, Toshiki, Ryu, Moon-Suhn, Ghosh, Manik C., Lee, Jaekwon, Rouault, Tracey A., Park, Myung Hee, Philpott, Caroline C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050543/
https://ncbi.nlm.nih.gov/pubmed/24843120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402732111
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