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PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis

Developing erythrocytes take up exceptionally large amounts of iron, which must be transferred to mitochondria for incorporation into heme. This massive iron flux must be precisely controlled to permit the coordinated synthesis of heme and hemoglobin while avoiding the toxic effects of chemically re...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Ryu, Moon-Suhn, Zhang, Deliang, Protchenko, Olga, Shakoury-Elizeh, Minoo, Philpott, Caroline C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409075/
https://ncbi.nlm.nih.gov/pubmed/28375153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90519
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