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PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis

Developing erythrocytes take up exceptionally large amounts of iron, which must be transferred to mitochondria for incorporation into heme. This massive iron flux must be precisely controlled to permit the coordinated synthesis of heme and hemoglobin while avoiding the toxic effects of chemically re...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Ryu, Moon-Suhn, Zhang, Deliang, Protchenko, Olga, Shakoury-Elizeh, Minoo, Philpott, Caroline C.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409075/
https://ncbi.nlm.nih.gov/pubmed/28375153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90519
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