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PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis
Developing erythrocytes take up exceptionally large amounts of iron, which must be transferred to mitochondria for incorporation into heme. This massive iron flux must be precisely controlled to permit the coordinated synthesis of heme and hemoglobin while avoiding the toxic effects of chemically re...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5409075/ https://ncbi.nlm.nih.gov/pubmed/28375153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90519 |
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