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PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis
Developing erythrocytes take up exceptionally large amounts of iron, which must be transferred to mitochondria for incorporation into heme. This massive iron flux must be precisely controlled to permit the coordinated synthesis of heme and hemoglobin while avoiding the toxic effects of chemically re...
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| Veröffentlicht in: | J Clin Invest |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5409075/ https://ncbi.nlm.nih.gov/pubmed/28375153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90519 |
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