Replication of the 2,6-Diamino-4-hydroxy-N(5)-(methyl)-formamidopyrimidine (MeFapy-dGuo) Adduct by Eukaryotic DNA Polymerases

[Image: see text] N(6)-(2-Deoxy-D-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy-dGuo) has been identified as a stable DNA adduct that arises from the reaction of DNA with a variety of methylating agents. Since this lesion persists in DNA and may contribu...

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Detalhes bibliográficos
Main Authors: Christov, Plamen P., Yamanaka, Kinrin, Choi, Jeong-Yun, Takata, Kei-ichi, Wood, Richard D., Guengerich, F. Peter, Lloyd, R. Stephen, Rizzo, Carmelo J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682502/
https://ncbi.nlm.nih.gov/pubmed/22721435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300113e
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