Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo

The phosphatidylinositol 3-kinase (PI3-K)/Akt and mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in cell survival and proliferation and is often aberrantly activated in many types of cancer. The mTOR kinase protein, one of the key molecules in this pathway, has been sho...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xie, Hua, Lee, Mee-Hyun, Zhu, Feng, Reddy, Kanamata, Huang, Zunnan, Kim, Dong Joon, Li, Yan, Peng, Cong, Lim, Do Young, Kang, Soouk, Jung, Sung Keun, Li, Xiang, Li, Haitao, Ma, Weiya, Lubet, Ronald A., Ding, Jian, Bode, Ann M., Dong, Zigang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681861/
https://ncbi.nlm.nih.gov/pubmed/23536724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1241
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