Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo

The phosphatidylinositol 3-kinase (PI3-K)/Akt and mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in cell survival and proliferation and is often aberrantly activated in many types of cancer. The mTOR kinase protein, one of the key molecules in this pathway, has been sho...

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Autori principali: Xie, Hua, Lee, Mee-Hyun, Zhu, Feng, Reddy, Kanamata, Huang, Zunnan, Kim, Dong Joon, Li, Yan, Peng, Cong, Lim, Do Young, Kang, Soouk, Jung, Sung Keun, Li, Xiang, Li, Haitao, Ma, Weiya, Lubet, Ronald A., Ding, Jian, Bode, Ann M., Dong, Zigang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681861/
https://ncbi.nlm.nih.gov/pubmed/23536724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1241
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