Identification of an Aurora kinase inhibitor specific for the Aurora B isoform

Aurora kinases play an important role in chromosome alignment, segregation, and cytokinesis during mitosis. In the present study, we used a ligand-docking method to explore the novel scaffold of potential Aurora B inhibitors. One thousand compounds from our in-house compound library were screened ag...

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Détails bibliographiques
Auteurs principaux: Xie, Hua, Lee, Mee-Hyun, Zhu, Feng, Reddy, Kanamata, Peng, Cong, Li, Yan, Lim, Do Young, Kim, Dong Joon, Li, Xiang, Kang, Soouk, Li, Haitao, Ma, Weiya, Lubet, Ronald A., Ding, Jian, Bode, Ann M., Dong, Zigang
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549034/
https://ncbi.nlm.nih.gov/pubmed/23117881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2784
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