Th Cells Promote CTL Survival and Memory via Acquired pMHC-I and Endogenous IL-2 and CD40L Signaling and by Modulating Apoptosis-Controlling Pathways

Involvement of CD4(+) helper T (Th) cells is crucial for CD8(+) cytotoxic T lymphocyte (CTL)-mediated immunity. However, CD4(+) Th’s signals that govern CTL survival and functional memory are still not completely understood. In this study, we assessed the role of CD4(+) Th cells with acquired antige...

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Detalhes bibliográficos
Main Authors: Umeshappa, Channakeshava Sokke, Xie, Yufeng, Xu, Shulin, Nanjundappa, Roopa Hebbandi, Freywald, Andrew, Deng, Yulin, Ma, Hong, Xiang, Jim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681805/
https://ncbi.nlm.nih.gov/pubmed/23785406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064787
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