CD154 and IL-2 Signaling of CD4(+) T Cells Play a Critical Role in Multiple Phases of CD8(+) CTL Responses Following Adenovirus Vaccination

Adenoviral (AdV) vectors represent most commonly utilized viral vaccines in clinical studies. While the role of CD8(+) cytotoxic T lymphocyte (CTL) responses in mediating AdV-induced protection is well understood, the involvement of CD4(+) T cell-provided signals in the development of functional CD8...

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Detalhes bibliográficos
Main Authors: Sokke Umeshappa, Channakeshava, Hebbandi Nanjundappa, Roopa, Xie, Yufeng, Freywald, Andrew, Deng, Yulin, Ma, Hong, Xiang, Jim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465321/
https://ncbi.nlm.nih.gov/pubmed/23071696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047004
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