Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines

Peptide-major histocompatibility complex class II (pMHCII)-based nanomedicines displaying tissue-specific autoantigenic epitopes can blunt specific autoimmune conditions by re-programming cognate antigen-experienced CD4+ T-cells into disease-suppressing T-regulatory type 1 (TR1) cells. Here, we show...

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Publicado no:Nat Commun
Main Authors: Umeshappa, Channakeshava Sokke, Singha, Santiswarup, Blanco, Jesus, Shao, Kun, Nanjundappa, Roopa Hebbandi, Yamanouchi, Jun, Parés, Albert, Serra, Pau, Yang, Yang, Santamaria, Pere
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517389/
https://ncbi.nlm.nih.gov/pubmed/31089130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09893-5
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