Differential requirements of CD4(+) T-cell signals for effector cytotoxic T-lymphocyte (CTL) priming and functional memory CTL development at higher CD8(+) T-cell precursor frequency

Increased CD8(+) T-cell precursor frequency (PF) precludes the requirement of CD4(+) helper T (Th) cells for primary CD8(+) cytotoxic T-lymphocyte (CTL) responses. However, the key questions of whether unhelped CTLs generated at higher PF are functional effectors, and whether unhelped CTLs can diffe...

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Autores principales: Umeshappa, Channakeshava S, Nanjundappa, Roopa H, Xie, Yufeng, Freywald, Andrew, Xu, Qingyong, Xiang, Jim
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2013
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719941/
https://ncbi.nlm.nih.gov/pubmed/23113741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12033
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