The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon

Ligands of pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) stimulate innate and adaptive immune responses and are considered as potent adjuvants. Combinations of ligands might act in synergy to induce stronger and broader immune responses compared to stand-alone ligands. Al...

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Main Authors: Knudsen, Maria L., Johansson, Daniel X., Kostic, Linda, Nordström, Eva K. L., Tegerstedt, Karin, Pasetto, Anna, Applequist, Steven E., Ljungberg, Karl, Sirard, Jean-Claude, Liljeström, Peter
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681802/
https://ncbi.nlm.nih.gov/pubmed/23785460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065964
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