Superior Induction of T Cell Responses to Conserved HIV-1 Regions by Electroporated Alphavirus Replicon DNA Compared to That with Conventional Plasmid DNA Vaccine

Vaccination using “naked” DNA is a highly attractive strategy for induction of pathogen-specific immune responses; however, it has been only weakly immunogenic in humans. Previously, we constructed DNA-launched Semliki Forest virus replicons (DREP), which stimulate pattern recognition receptors and...

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Detalles Bibliográficos
Main Authors: Knudsen, Maria L., Mbewe-Mvula, Alice, Rosario, Maximillian, Johansson, Daniel X., Kakoulidou, Maria, Bridgeman, Anne, Reyes-Sandoval, Arturo, Nicosia, Alfredo, Ljungberg, Karl, Hanke, Tomáš, Liljeström, Peter
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318663/
https://ncbi.nlm.nih.gov/pubmed/22318135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06535-11
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