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The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon

Ligands of pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) stimulate innate and adaptive immune responses and are considered as potent adjuvants. Combinations of ligands might act in synergy to induce stronger and broader immune responses compared to stand-alone ligands. Al...

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Detalhes bibliográficos
Main Authors: Knudsen, Maria L., Johansson, Daniel X., Kostic, Linda, Nordström, Eva K. L., Tegerstedt, Karin, Pasetto, Anna, Applequist, Steven E., Ljungberg, Karl, Sirard, Jean-Claude, Liljeström, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681802/
https://ncbi.nlm.nih.gov/pubmed/23785460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065964
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