An inherently bi-functional subset of Foxp3(+) T helper cells is controlled by the transcription factor Eos

At sites of inflammation, certain regulatory T cells (Treg cells) can undergo rapid reprogramming into helper-like cells, without loss of the transcription factor Foxp3. We show that reprogramming is controlled by down-regulation of the transcription factor Eos (Ikzf4), an obligate co-repressor for...

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Detalhes bibliográficos
Main Authors: Sharma, Madhav D., Huang, Lei, Choi, Jeong-Hyeon, Lee, Eun-Joon, Wilson, James M., Lemos, Henrique, Pan, Fan, Blazar, Bruce R., Pardoll, Drew M., Mellor, Andrew L, Shi, Huidong, Munn, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681093/
https://ncbi.nlm.nih.gov/pubmed/23684987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.01.013
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