Comprehensive Experimental and Computational Analysis of Binding Energy Hot Spots at the NF-κB Essential Modulator (NEMO)/IKKβ Protein-Protein Interface

We report a comprehensive analysis of binding energy hot spots at the protein-protein interaction (PPI) interface between NF-κB Essential Modulator (NEMO) and IκB kinase subunit β (IKKβ), an interaction that is critical for NF-κB pathway signaling, using experimental alanine scanning mutagenesis and...

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Hauptverfasser: Golden, Mary S., Cote, Shaun M., Sayeg, Marianna, Zerbe, Brandon S., Villar, Elizabeth A., Beglov, Dmitri, Sazinsky, Stephen L., Georgiadis, Rosina M., Vajda, Sandor, Kozakov, Dima, Whitty, Adrian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680600/
https://ncbi.nlm.nih.gov/pubmed/23506214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja400914z
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