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STAT3 Activates miR-155 in Th17 Cells and Acts in Concert to Promote Experimental Autoimmune Uveitis

PURPOSE. MicroRNA-155 (miR-155) and STAT3 are implicated in uveitis and pathogenic mechanisms of CNS autoimmune diseases. In our study, we used miR-155(−/−) mice and mice with targeted STAT3 deletion in T cells (CD4-STAT3KO) to investigate roles of miR-155 and STAT3 in the development of experimenta...

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Hlavní autoři: Escobar, Thelma, Yu, Cheng-Rong, Muljo, Stefan A., Egwuagu, Charles E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680004/
https://ncbi.nlm.nih.gov/pubmed/23674757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-11937
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