Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a

Development of tolerance to endotoxin prevents sustained hyper inflammation during systemic infections. Here we report for the first time that chronic morphine treatment tempers endotoxin tolerance resulting in persistent inflammation, septicemia and septic shock. Morphine was found to down-regulate...

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Hauptverfasser: Banerjee, Santanu, Meng, Jingjing, Das, Subhas, Krishnan, Anitha, Haworth, Justin, Charboneau, Richard, Zeng, Yan, Ramakrishnan, Sundaram, Roy, Sabita
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679508/
https://ncbi.nlm.nih.gov/pubmed/23756365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01977
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