Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a

Development of tolerance to endotoxin prevents sustained hyper inflammation during systemic infections. Here we report for the first time that chronic morphine treatment tempers endotoxin tolerance resulting in persistent inflammation, septicemia and septic shock. Morphine was found to down-regulate...

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Main Authors: Banerjee, Santanu, Meng, Jingjing, Das, Subhas, Krishnan, Anitha, Haworth, Justin, Charboneau, Richard, Zeng, Yan, Ramakrishnan, Sundaram, Roy, Sabita
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679508/
https://ncbi.nlm.nih.gov/pubmed/23756365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01977
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