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Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a
Development of tolerance to endotoxin prevents sustained hyper inflammation during systemic infections. Here we report for the first time that chronic morphine treatment tempers endotoxin tolerance resulting in persistent inflammation, septicemia and septic shock. Morphine was found to down-regulate...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3679508/ https://ncbi.nlm.nih.gov/pubmed/23756365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01977 |
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