Rare APOA5 promoter variants associated with paradoxical HDL cholesterol decrease in response to fenofibric acid therapy

Individuals with mixed dyslipidemia, including high triglycerides (TGs) and low high density lipoprotein cholesterol (HDL-C), have increased risk for coronary events. We examined the effect of rare genetic variants in the APOA5 gene region on plasma HDL-C, apolipoprotein A-I (apoA-I), and TG respons...

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Huvudupphovsmän: Brautbar, Ariel, Barbalic, Maja, Chen, Fengju, Belmont, John, Virani, Salim S., Scherer, Steve, Hegele, Robert A., Ballantyne, Christie M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Biochemistry and Molecular Biology 2013
Ämnen:
Patient-Oriented and Epidemiological Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679399/
https://ncbi.nlm.nih.gov/pubmed/23633496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M034132
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