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Adiponectin regulates bone mass accrual through two opposite mechanisms, one local and one central, that both rely on FoxO1
The synthesis of adiponectin, an adipokine with ill-defined functions in animals fed a normal diet, is enhanced by the osteoblast-derived hormone osteocalcin. Here we show that adiponectin signals back in osteoblasts to hamper their proliferation and favor their apoptosis, altogether decreasing bone...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3679303/ https://ncbi.nlm.nih.gov/pubmed/23684624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.04.009 |
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