Adiponectin regulates bone mass accrual through two opposite mechanisms, one local and one central, that both rely on FoxO1

The synthesis of adiponectin, an adipokine with ill-defined functions in animals fed a normal diet, is enhanced by the osteoblast-derived hormone osteocalcin. Here we show that adiponectin signals back in osteoblasts to hamper their proliferation and favor their apoptosis, altogether decreasing bone...

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Библиографические подробности
Главные авторы: Kajimura, Daisuke, Lee, Ha Won, Riley, Kyle J., Arteaga-Solis, Emilio, Ferron, Mathieu, Zhou, Bin, Clarke, Christopher J., Hannun, Yusuf A., DePinho, Ronald A, Guo, Edward X., Mann, J. John, Karsenty, Gerard
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679303/
https://ncbi.nlm.nih.gov/pubmed/23684624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.04.009
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