Shigella antigen-specific B memory cells are associated with decreased disease severity in subjects challenged with wild-type Shigella flexneri 2a

The role of Shigella-specific B memory (B(M)) in protection has not been evaluated in human challenge studies. We utilized cryopreserved pre- and post-challenge peripheral blood mononuclear cells and sera from wild-type Shigella flexneri 2a (wt-2457T) challenges. Challenged volunteers were either na...

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Autores principales: Wahid, Rezwanul, Simon, Jakub K., Picking, Wendy L., Kotloff, Karen L., Levine, Myron M., Sztein, Marcelo B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679276/
https://ncbi.nlm.nih.gov/pubmed/23649043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2013.03.009
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