Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells

Gemcitabine is a deoxycytidine analog used for the treatment of a wide range of solid tumors. Its efficacy is however often reduced due to the development of resistance. Ribonucleotide reductase M1 subunit (RRM1) is a key determinant of gemcitabine resistance, and tumor cells that overexpress RRM1 a...

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Detalhes bibliográficos
Main Authors: Wonganan, Piyanuch, Chung, Woon-Gye, Zhu, Saijie, Kiguchi, Kaoru, DiGiovanni, John, Cui, Zhengrong
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679115/
https://ncbi.nlm.nih.gov/pubmed/22785206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.20843
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