DC260126: A Small-Molecule Antagonist of GPR40 that Protects against Pancreatic β-Cells Dysfunction in db/db Mice

G protein-coupled receptor 40 (GPR40) mediates both acute and chronic effects of free fatty acids (FFAs) on insulin secretion. However, it remains controversial whether inhibition of GPR40 would be beneficial in prevention of type 2 diabetes. This study is designed to evaluate the potential effects...

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Bibliographische Detailangaben
Hauptverfasser: Sun, Peng, Wang, Ting, Zhou, Yuren, Liu, Hong, Jiang, Hualiang, Zhu, Weiliang, Wang, Heyao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679087/
https://ncbi.nlm.nih.gov/pubmed/23776696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066744
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