Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

1. Long chain fatty acids have recently been identified as agonists for the G protein-coupled receptors GPR40 and GPR120. Here, we present the first description of GW9508, a small-molecule agonist of the fatty acid receptors GPR40 and GPR120. In addition, we also describe the pharmacology of GW1100,...

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Hlavní autoři: Briscoe, Celia P, Peat, Andrew J, McKeown, Stephen C, Corbett, David F, Goetz, Aaron S, Littleton, Thomas R, McCoy, David C, Kenakin, Terry P, Andrews, John L, Ammala, Carina, Fornwald, James A, Ignar, Diane M, Jenkinson, Stephen
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751878/
https://ncbi.nlm.nih.gov/pubmed/16702987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706770
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