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Functional Assessment of Population and Tumor-Associated APE1 Protein Variants
Apurinic/apyrimidinic endonuclease 1 (APE1) is the predominant AP site repair enzyme in mammals. APE1 also maintains 3′–5′ exonuclease and 3′-repair activities, and regulates transcription factor DNA binding through its REF-1 function. Since complete or severe APE1 deficiency leads to embryonic leth...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3679070/ https://ncbi.nlm.nih.gov/pubmed/23776569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065922 |
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