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Functional characterization of Ape1 variants identified in the human population

Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions. Ape1 is the major human repair enzyme for abasic sites and incises the phosphodiester backbone 5′ to the lesion to initiate a cascade of events aimed at removing the AP moiety and maintaining genetic integrity. Through...

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Main Authors: Hadi, Masood Z., Coleman, Matthew A., Fidelis, Krzysztof, Mohrenweiser, Harvey W., Wilson, David M.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2000
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC110798/
https://ncbi.nlm.nih.gov/pubmed/11024165
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