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Secondary Genomic Rearrangements Involving Immunoglobulin or MYC Loci Show Similar Prevalences in Hyperdiploid and Nonhyperdiploid Myeloma Tumors

The pathogenesis of multiple myeloma (MM) is thought to involve at least two pathways, which generate hyperdiploid (HRD) or nonhyperdiploid (NHRD) tumors, respectively. Apart from chromosome content, the two pathways are distinguished by five primary immunoglobulin heavy chain (IGH) rearrangements (...

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Detalles Bibliográficos
Main Authors: Gabrea, Ana, Martelli, Maria Luisa, Qi, Ying, Roschke, Anna, Barlogie, Bart, Shaughnessy, John D., Sawyer, Jeffrey R., Kuehl, W. Michael
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3678755/
https://ncbi.nlm.nih.gov/pubmed/18381641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.20563
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