A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability

RATIONALE: The small GTPase Rac is critical to vascular endothelial functions, yet its regulation in endothelial cells remains unclear. Understanding the upstream pathway may delineate Rac activation mechanisms and its role in maintaining vascular endothelial barrier integrity. OBJECTIVE: By investi...

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Bibliografische gegevens
Hoofdauteurs: Naikawadi, Ram P., Cheng, Ni, Vogel, Stephen M., Qian, Feng, Wu, Dianqing, Malik, Asrar B., Ye, Richard D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677960/
https://ncbi.nlm.nih.gov/pubmed/22965143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.273078
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