A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability

RATIONALE: The small GTPase Rac is critical to vascular endothelial functions, yet its regulation in endothelial cells remains unclear. Understanding the upstream pathway may delineate Rac activation mechanisms and its role in maintaining vascular endothelial barrier integrity. OBJECTIVE: By investi...

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Detaylı Bibliyografya
Asıl Yazarlar: Naikawadi, Ram P., Cheng, Ni, Vogel, Stephen M., Qian, Feng, Wu, Dianqing, Malik, Asrar B., Ye, Richard D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677960/
https://ncbi.nlm.nih.gov/pubmed/22965143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.273078
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