Mature T-cell Lymphomagenesis Induced by Retroviral Insertional Activation of Janus Kinase 1

Retroviral vectors (RVs) are powerful tools in clinical gene therapy. However, stable genomic integration of RVs can be oncogenic, as reported in several animal models and in clinical trials. Previously, we observed that T-cell receptor (TCR) polyclonal mature T cells are resistant to transformation...

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Detalhes bibliográficos
Main Authors: Heinrich, Tim, Rengstl, Benjamin, Muik, Alexander, Petkova, Mina, Schmid, Frederike, Wistinghausen, Robin, Warner, Kathrin, Crispatzu, Giuliano, Hansmann, Martin-Leo, Herling, Marco, von Laer, Dorothee, Newrzela, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677306/
https://ncbi.nlm.nih.gov/pubmed/23609016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.67
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