Retroviral Insertional Mutagenesis Can Contribute to Immortalization of Mature T Lymphocytes

Several cases of T-cell leukemia caused by gammaretroviral insertional mutagenesis in children treated for x-linked severe combined immunodeficiency (SCID) by transplantation of autologous gene-modified stem cells were reported. In a comparative analysis, we recently showed that mature T cells, on t...

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Bibliographic Details
Main Authors: Newrzela, Sebastian, Cornils, Kerstin, Heinrich, Tim, Schläger, Julia, Yi, Ji-Hee, Lysenko, Olga, Kimpel, Janine, Fehse, Boris, von Laer, Dorothee
Format: Artigo
Language:Inglês
Published: ScholarOne 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321800/
https://ncbi.nlm.nih.gov/pubmed/21826372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2010.00193
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