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Multiple sensors ensure guide strand selection in human RNAi pathways
Small RNAs guide RNA-induced silencing complexes (RISCs) to bind to cognate mRNA transcripts and trigger silencing of protein expression during RNA interference (RNAi) in eukaryotes. A fundamental aspect of this process is the asymmetric loading of one strand of a short interfering RNA (siRNA) or mi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677279/ https://ncbi.nlm.nih.gov/pubmed/23531496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.037424.112 |
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