Dual Targeting of the Cyclin/Rb/E2F and Mitochondrial Pathways in Mantle Cell Lymphoma with the Translation Inhibitor Silvestrol

PURPOSE: During cell cycle progression, D-cyclins activate cyclin-dependent kinases (CDKs) 4/6 to inactivate Rb, permitting E2F1-mediated S-phase gene transcription. This critical pathway is typically deregulated in cancer, and novel inhibitory strategies would be effective in a variety of tumors. T...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Alinari, Lapo, Prince, Courtney J., Edwards, Ryan B., Towns, William, Mani, Rajeswaran, Lehman, Amy, Zhang, Xiaoli, Jarjoura, David, Pan, Li, Kinghorn, A. Douglas, Grever, Michael R., Baiocchi, Robert A., Lucas, David M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677230/
https://ncbi.nlm.nih.gov/pubmed/22791882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0839
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