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Probing Sequence-specific DNA Flexibility in A-tracts and Pyrimidine-purine Steps by NMR (13)C Relaxation and MD Simulations
Sequence-specific DNA flexibility plays a key role in a variety of cellular interactions that are critical for gene packaging, expression, and regulation. Yet, few studies have experimentally explored the sequence dependence of DNA dynamics that occur on biologically relevant timescales. Here, we us...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3676944/ https://ncbi.nlm.nih.gov/pubmed/23035755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3009517 |
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