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Constructing RNA dynamical ensembles by combining MD and motionally decoupled NMR RDCs: new insights into RNA dynamics and adaptive ligand recognition

We describe a strategy for constructing atomic resolution dynamical ensembles of RNA molecules, spanning up to millisecond timescales, that combines molecular dynamics (MD) simulations with NMR residual dipolar couplings (RDC) measured in elongated RNA. The ensembles are generated via a Monte Carlo...

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Bibliografische gegevens
Hoofdauteurs: Frank, Aaron T., Stelzer, Andrew C., Al-Hashimi, Hashim M., Andricioaei, Ioan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2009
Onderwerpen:
RNA
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699496/
https://ncbi.nlm.nih.gov/pubmed/19369218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp156
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