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HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade

Treatment with histone deacetylase inhibitors (HDACI) results in potent cytotoxicity of a variety of cancer cell types, and these drugs are used clinically to treat hematological tumors. They are known to repress the transcription of ERBB2 and many other oncogenes, but little is known about this mec...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kim, Yoon Jung, Greer, Celeste B., Cecchini, Katharine R., Harris, Lyndsay N., Tuck, David P., Kim, Tae Hoon
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676447/
https://ncbi.nlm.nih.gov/pubmed/23435418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.32
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