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HDAC inhibitors induce transcriptional repression of high copy number genes in breast cancer through elongation blockade
Treatment with histone deacetylase inhibitors (HDACI) results in potent cytotoxicity of a variety of cancer cell types, and these drugs are used clinically to treat hematological tumors. They are known to repress the transcription of ERBB2 and many other oncogenes, but little is known about this mec...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3676447/ https://ncbi.nlm.nih.gov/pubmed/23435418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.32 |
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