Substrate-specific structural rearrangements of human Dicer

Dicer plays a central role in RNA interference pathways by cleaving double-stranded RNAs (dsRNAs) to produce small regulatory RNAs. Human Dicer can process long double-stranded and hairpin precursor RNAs to yield short interfering RNAs (siRNAs) or microRNAs (miRNAs), respectively. Previous studies h...

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Autors principals: Taylor, David W., Ma, Enbo, Shigematsu, Hideki, Cianfrocco, Michael A., Noland, Cameron L., Nagayama, Kuniaki, Nogales, Eva, Doudna, Jennifer A., Wang, Hong-Wei
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676429/
https://ncbi.nlm.nih.gov/pubmed/23624860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2564
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