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Effect of ABCB1 polymorphisms and atorvastatin on sitagliptin pharmacokinetics in healthy volunteers

OBJECTIVES: The objectives of this study were to determine if ABCB1 polymorphisms are associated with interindividual variability in sitagliptin pharmacokinetics, and if atorvastatin alters the pharmacokinetic disposition of sitagliptin in healthy volunteers. METHODS: In this open-label, randomized,...

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Main Authors: Aquilante, Christina L., Wempe, Michael F., Sidhom, Maha S., Kosmiski, Lisa A., Predhomme, Julie A.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676426/
https://ncbi.nlm.nih.gov/pubmed/23407853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-013-1475-y
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