Differential Effects of Tipranavir plus Ritonavir on Atorvastatin or Rosuvastatin Pharmacokinetics in Healthy Volunteers

To identify pharmacokinetic (PK) drug-drug interactions between tipranavir-ritonavir (TPV/r) and rosuvastatin and atorvastatin, we conducted two prospective, open-label, single-arm, two-period studies. The geometric mean (GM) ratio was 1.37 (90% confidence interval [CI], 1.15 to 1.62) for the area u...

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Detalhes bibliográficos
Main Authors: Pham, P. A., la Porte, C. J. L., Lee, L. S., van Heeswijk, R., Sabo, J. P., Elgadi, M. M., Piliero, P. J., Barditch-Crovo, P., Fuchs, E., Flexner, C., Cameron, D. W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764168/
https://ncbi.nlm.nih.gov/pubmed/19667285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00449-09
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