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Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers

Polymorphisms in drug transporter genes and/or drug-metabolising enzyme genes may contribute to inter-individual variability in rosiglitazone pharmacokinetics in humans. We sought to determine the joint effects of polymorphisms in the SLCO1B1 drug transporter gene and the cytochrome P450 (CYP) 2C8-m...

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Detalhes bibliográficos
Main Authors: Aquilante, Christina L, Bushman, Lane R, Knutsen, Shannon D, Burt, Lauren E, Rome, Lucille Capo, Kosmiski, Lisa A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525178/
https://ncbi.nlm.nih.gov/pubmed/19129086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-7364-3-1-7
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