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A Perfluoroaryl-Cysteine S(N)Ar Chemistry Approach to Unprotected Peptide Stapling
We report the discovery of a facile transformation between perfluoroaromatic molecules and a cysteine thiolate, which is arylated at room temperature. This new approach enabled us to selectively modify cysteine residues in unprotected peptides, providing access to variants containing rigid perfluoro...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3675880/ https://ncbi.nlm.nih.gov/pubmed/23560559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja400119t |
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