β-Amyloid (Aβ) Oligomers Impair Brain-derived Neurotrophic Factor Retrograde Trafficking by Down-regulating Ubiquitin C-terminal Hydrolase, UCH-L1

We previously found that BDNF-dependent retrograde trafficking is impaired in AD transgenic mouse neurons. Utilizing a novel microfluidic culture chamber, we demonstrate that Aβ oligomers compromise BDNF-mediated retrograde transport by impairing endosomal vesicle velocities, resulting in impaired d...

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Detalhes bibliográficos
Main Authors: Poon, Wayne W., Carlos, Anthony J., Aguilar, Brittany L., Berchtold, Nicole C., Kawano, Crystal K., Zograbyan, Vahe, Yaopruke, Tim, Shelanski, Michael, Cotman, Carl W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675626/
https://ncbi.nlm.nih.gov/pubmed/23599427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463711
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