Rapamycin and Interleukin-1β Impair Brain-derived Neurotrophic Factor-dependent Neuron Survival by Modulating Autophagy

The mammalian target of rapamycin (mTOR) pathway has multiple important physiological functions, including regulation of protein synthesis, cell growth, autophagy, and synaptic plasticity. Activation of mTOR is necessary for the many beneficial effects of brain-derived neurotrophic factor (BDNF), in...

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Detalhes bibliográficos
Main Authors: Smith, Erica D., Prieto, G. Aleph, Tong, Liqi, Sears-Kraxberger, Ilse, Rice, Jeffrey D., Steward, Oswald, Cotman, Carl W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110274/
https://ncbi.nlm.nih.gov/pubmed/24917666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568659
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