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IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome trafficking
BACKGROUND: Pro-inflammatory cytokines accumulate in the brain with age and Alzheimer’s disease and can impair neuron health and cognitive function. Brain-derived neurotrophic factor (BDNF) is a key neurotrophin that supports neuron health, function, and synaptic plasticity. The pro-inflammatory cyt...
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| Publicado no: | J Neuroinflammation |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5290618/ https://ncbi.nlm.nih.gov/pubmed/28153028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0803-z |
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